RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery
- Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Abstract
RNAi in Schizosaccharomyces pombe is critical for centromeric heterochromatin formation. It has remained unclear, however, whether RNAi also regulates the expression of protein-coding loci. In the April 1, 2012, issue of Genes & Development, Woolcock and colleagues (pp. 683–667) reported an elegant mechanism for the conditional RNAi-mediated repression of stress response genes involving association with Dcr1 at the nuclear pore. Unexpectedly, the initial targeting of RNAi components to these genes does not require small RNA guides.
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↵1 Corresponding author.
E-mail danesh{at}hms.harvard.edu.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.191155.112.
- Copyright © 2012 by Cold Spring Harbor Laboratory Press
