Migration of Monocytes/Macrophages In Vitro and In Vivo Is Accompanied by MMP12-dependent Tunnel Formation and by Neovascularization
This extract was created in the absence of an abstract.
Excerpt
Migration of cells within tissues often requires the proteolytic destruction of the extracellular matrix (ECM).There is a large body of evidence that shows the involvement of matrix degrading enzymes, in particular the metalloproteases (MMP) and their inhibitors (TIMPS), inmany physiological and pathological processes related tocell movement in general (Amorino et al. 1998; Hiraokaet al. 1998; Murphy and Gavrilovic 1999; Shapiro 1999;Stetler-Stevenson 1999; Levine et al. 2000) and to angiogenesis in particular (Werb et al. 1999; Moldovan et al.2000; Libby and Schonbeck 2001). However, the fate ofthe tracks created within the matrix by migrating cells(Fig. 1a), which we called tunnels (Moldovan et al. 2000;Moldovan 2002), remain largely unexplored. Do they really exist? How long do they survive after a cell movesaway? Do they collapse, are they passively filled by otherproteins, or is there an active mechanism of tissue repairbehind the migrating cells...
