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Volume 8, Issue 5

The characterization of carried in the general population Open Access

Abstract

is a common cause of respiratory tract infection, particularly otitis media in children, whilst it is also associated with the onset of exacerbation in chronic obstructive pulmonary disease in adults. Despite the need for an efficacious vaccine against , no candidates have progressed to clinical trial. This study, therefore, aimed to characterize the diversity of isolated from the upper respiratory tract of healthy children and adults, to gain a better understanding of the epidemiology of and the distribution of genes associated with virulence factors, to aid vaccine efforts. Isolates were sequenced and the presence of target genes reported. Contrary to prevailing data, this study found that lipooligosaccharide (LOS) B serotypes are not exclusively associated with 16S type 1. In addition, a particularly low prevalence of LOS B and high prevalence of LOS C serotypes was observed. isolates showed low prevalence of antimicrobial resistance and a high gene prevalence for a number of the target genes investigated: (also known as ), , , , , (also known as ), , , , , , , , and , , , , , mod, , , and .

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): AMR , carriage , epidemiology , Moraxella catarrhalis and virulence
Funding
This study was supported by the:
  • Bupa Foundation
    • Principle Award Recipient: StuartC. Clarke
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-05-26
2024-04-28
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The characterization of Moraxella catarrhalis carried in the general population
M Gen 8, 000820 (2022); https://doi.org/10.1099/mgen.0.000820
/content/journal/mgen/10.1099/mgen.0.000820
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