Clinical StudiesNitric Oxide and Oxidative Stress in Atherosclerotic Renovascular Hypertension: Effect of Endovascular Treatment
Section snippets
Patient Population
Between March 2000 and April 2002, we recruited consecutive patients referred to the interventional radiology unit for the treatment of renal artery stenosis. They had renal artery stenosis confirmed by color Doppler ultrasonography (US). Twenty-one subjects (16 men and 5 women; mean age, 60.4 years ± 14.7 [SD]; body mass index, 21.4 kg/m2 ± 3.4) were enrolled in the study. All subjects gave written informed consent.
Subjects with systolic blood pressures of 130–139 mm Hg and diastolic pressures
RESULTS
Renal artery stenosis was rightsided in eight patients and left-sided in 13. Nine patients had stenoses that were relatively moderate (50%–70%) and 12 had stenoses greater than 70%. Nineteen patients with ostial stenoses required stent placement. No adverse event in any patient occurred within 30 days of the procedure. Renal artery stenosis recurred after 7 months in one diabetic patient treated with stent placement. This patient was treated again by endovascular methods. All other follow-up
DISCUSSION
Oxygen free radicals or activated oxygen have been implicated in diverse environmental stresses and appear to participate commonly in most degenerative conditions. The peroxidation of lipids and the cross-linking and inactivation of proteins and mutations in DNA are typical consequences of free radicals, but because the reactions occur quickly and are often components of complex chain reactions, we can usually detect only their “footprints.” The mechanisms by which oxygen radicals damage
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Cited by (18)
Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats
2020, Journal of Functional FoodsCitation Excerpt :In fact, lipid peroxidation is frequently correlated to the progression of renal diseases and cardiovascular complications (Krata, Zagożdżon, Foroncewicz, & Mucha, 2017). Superoxide anion, admittedly one of the most damaging ROS is activated by Ang-II through NAD(P)H oxidase which scavenges nitric oxide (NO) to disrupt the vasorelaxation that is dependent on endothelium by decreasing its bioavailability as well as to generate peroxynitrite (ONOO−) that causes devastating cellular damages by creating nitrosative stress (Modaresi, Nafar, & Sahraei, 2015; Parildar et al., 2003; Sawant & Bodhankar, 2016). Malondialdehyde (MDA), advanced protein oxidation products (APOP), and nitric oxide (NO) are three important biomarkers of oxidative stress whose levels in plasma, kidney and heart tissue homogenates have been evaluated in this study.
Atherosclerotic renal artery stenosis - Diagnosis and treatment
2011, Mayo Clinic ProceedingsCitation Excerpt :Renin has also been associated with vasculotoxic and nephrotoxic effects.32 Oxidative stress has been implicated in the ischemic and hypertensive parenchymal renal injury related to ARAS.33,34 Clinical clues to the presence of ARAS are listed in Table 1.35
Endovascular Treatment of Peripheral Vascular Disease
2009, Current Problems in CardiologyCitation Excerpt :Renovascular hypertension in these patients correlates best with markers of oxidative stress.83 The oxidative stress pathway will normalize with successful revascularization.82,84 Early studies on revascularization in RAS failed to demonstrate a major benefit from angioplasty over the short term, but these studies had crossover rates from the medical therapy groups to revascularization as high as 44%, thereby underestimating the benefit of intervention on blood pressure levels in these patients.82,85
None of the authors have identified a potential conflict of interest.