| Accession Number | <strong>00042737-200103000-00011</strong>. |
|---|---|
| Author | Nunes, Amadeu C. R. a; Amaro, Pedro a; Macoas, Fernanda a; Cipriano, Augusta b; Martins, Irene b; Rosa, Albano a; Pimenta, Isidoro a; Donato, Antonio a; Freitas, Diniz a |
| Institution | Departments of (a)Gastroenterology and (b)Pathology, Coimbra University Hospital, Coimbra, Portugal |
| Title | |
| Source | European Journal of Gastroenterology & Hepatology. 13(3):279-282, March 2001. |
| Abstract | We report a case of fosinopril-induced prolonged cholestatic jaundice and pruritus in a 61-year-old man, with no previous hepatobiliary disease, who presented with asthenia, jaundice and itching 3 weeks after starting fosinopril therapy. Other drugs taken by the patient were not considered probable causes. The diagnostic evaluation showed no biliary obstruction and other possible causes of intra-hepatic cholestasis were excluded. Liver biopsy showed cholestasis without bile duct damage. The disease ran a severe course during the 2 months of hospitalization, with prolonged itching for 6 months, eventually controlled with oral naltrexone. Jaundice subsided after 4 months, with anicteric cholestasis persisting for more than 18 months. Similar occurrences have been reported with other inhibitors of angiotensin-converting enzyme (mostly captopril), but this is the first case of an important adverse reaction to fosinopril. (C) 2001 Lippincott Williams & Wilkins, Inc. |