ReviewThe Origins of Intracrine Hormone Action
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Cited by (36)
Could intracrine biology play a role in the pathogenesis of transmissable spongiform encephalopathies, Alzheimer's disease and other neurodegenerative diseases?
2014, American Journal of the Medical SciencesNew Insights into Target Organ Involvement in Hypertension
2009, Medical Clinics of North AmericaCitation Excerpt :This suggests that the possibility that similar benefit can be obtained in patients with non-Marfan's vascular dilatation should be explored. Considerable evidence has been developed over recent years to indicate that a variety of peptide factors, including hormones, growth factors, DNA binding proteins, enzymes, and others, can serve both as extracellular signaling molecules and also function in the intracellular space either after retention in the cells that synthesized them or after internalization by target cells.45–52 Early on we termed these factors intracrines and developed hypotheses regarding their biologic origins and the principles that regulate their function.45,46
Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone
2009, Cellular ImmunologyCitation Excerpt :In some cases, the peptide hormone is internalized from the extracellular space, whereas in others it is synthesized inside the cell in which it binds and functions. Both modes of action have been deemed “intracrine” and some peptide factors (e.g., parathyroid hormone-related protein, fibroblast growth factor, platelet-derived growth factor) use both intracrine modes [12]. The list of intracrines is growing (almost 40) and the binding sites include a variety of intracellular organelles, including the nucleus, the mitochondrion, and cytoplasmic elements.
Potential therapeutic implications of intracrine angiogenesis
2007, Medical HypothesesExpression of insulin-like growth factor-2 receptors on EL4 lymphoma cells overexpressing growth hormone
2007, Brain, Behavior, and ImmunityCitation Excerpt :Over the last 20 years, evidence has slowly accumulated to indicate that in addition to their well-established actions at the cell membrane, certain peptide hormones and growth factors can bind to sites within the cell and generate physiologic effects (Re, 2002).
TGF-β1 expression in EL4 lymphoma cells overexpressing growth hormone
2006, Cellular ImmunologyCitation Excerpt :Over the last 20 years, evidence has slowly accumulated to indicate that in addition to their well-established actions at the cell membrane, certain peptide hormones and growth factors can bind to sites within the cell and generate physiologic effects [1].