Human Milk Oligosaccharides Activate Epidermal Growth Factor Receptor and Protect Against Hypoxia-Induced Injuries in the Mouse Intestinal Epithelium and Caco2 Cells
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Keywords:
EGFR
human milk oligosaccharides
hypoxia
necrotizing enterocolitis
P38
Abbreviations used:
BM
breast milk
EGFR
epidermal growth factor receptor
FF
formula milk fed
FOS
fructo-oligosaccharides
GOS
galacto-oligosaccharides
HHMO
20 mg/mL HMOs group
HIF
hypoxia inducible factor
HMO
human milk oligosaccharides
IFOS
infant formula oligosaccharides
LHMO
5 mg/mL HMOs group
LSD
least significant difference
MHMO
10 mg/mL HMO group
NEC
necrotizing enterocolitis
P38
38KD MAPK
P-EGFR
phosphorylated epidermal growth factor receptor
P-P38
phosphorylated 38KD MAPK
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Supported by the National Key R&D Program of China (2017YFC1601800) and National Natural Science Foundation of China (31401668, 31601443).
Author disclosures: The authors report no conflicts of interest.
Copyright © 2020 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.