Hostname: page-component-848d4c4894-nr4z6 Total loading time: 0 Render date: 2024-05-01T04:22:14.931Z Has data issue: false hasContentIssue false

Epidemiology of Antimicrobial Resistance among Gram-Negative Organisms Recovered from Patients in a Multistate Network of Long-Term Care Facilities

Published online by Cambridge University Press:  02 January 2015

Ebbing Lautenbach*
Affiliation:
Division of Infectious Diseases, Department of Medicine, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Department of Biostatistics and Epidemiology, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Education and Research on Therapeutics, theUniversity of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Roseann Marsicano
Affiliation:
Silver Labs, Cherry Hill, New Jersey
Pam Tolomeo
Affiliation:
Center for Clinical Epidemiology and Biostatistics, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Michael Heard
Affiliation:
Silver Labs, Cherry Hill, New Jersey
Steve Serrano
Affiliation:
Silver Labs, Cherry Hill, New Jersey
Donald D. Stieritz
Affiliation:
Silver Labs, Cherry Hill, New Jersey
*
University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021 (ebbing@mail.med.upenn.edu)

Abstract

We identified 1,805 gram-negative organisms in cultures of urine samples obtained over a 10-month period from residents of 63 long-term care facilities. The prevalence of fluoroquinolone resistance in Escherichia coli was 51% (446 of 874 isolates), whereas the preva¬lences of ceftazidime and imipenem resistance in Klebsiella species were 26% and 6% (84 and 19 of 323 isolates), respectively. The prevalence of resistance varied significantly by facility type, size, and geographic location.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Smith, PW, Bennett, G, Bradley, S, et al.SHEA/APIC guideline: infection prevention and control in the long-term care facility. Infect Control Hosp Epidemiol 2008;29:785814.CrossRefGoogle ScholarPubMed
2.Viray, M, Linkin, D, Maslow, JN, et al.Longitudinal trends in antimicrobial susceptibilities across long term care facilities: emergence of fluoroquinolone resistance. Infect Control Hosp Epidemiol 2005;26:5662.Google Scholar
3.Strausbaugh, LJ, Crossley, KB, Nurse, BA, Thrupp, LD. Antimicrobial resistance in long-term care facilities. Infect Control Hosp Epidemiol 1996;17:129140.CrossRefGoogle ScholarPubMed
4.Smith, PW, Rusnak, PG. Infection prevention and control in the long-term-care facility: SHEA Long-Term-Care Committee and APIC Guidelines Committee. Infect Control Hosp Epidemiol 1997;18:831849.CrossRefGoogle ScholarPubMed
5.Yoshikawa, TT. Antimicrobial resistance and aging: beginning of the end of the antibiotic era? J Am Geriatr Soc 2002;50(suppl):S226229.CrossRefGoogle ScholarPubMed
6.Nicolle, LE, Strausbaugh, LJ, Garibaldi, RA. Infections and antibiotic resistance in nursing homes. Clin Microbiol Rev 1996;9:117.CrossRefGoogle ScholarPubMed
7. Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 18th informational supplement. Wayne, PA: CLSI, 2008:M100-S18.Google Scholar
8.Kleinbaum, DG, Kupper, LL, Morgenstern, H. Epidemiologie research:principles and quantitative methods. New York: Van Nostrand Reinhold; 1982.Google Scholar
9.Lipworth, AD, Hyle, EP, Fishman, NO, et al.Limiting the emergence of extended-spectrum β-lactamase-producing Enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventions. Infect Control Hosp Epidemiol 2006;27:27986.CrossRefGoogle ScholarPubMed
10.Urban, C, Bradford, PA, Tuckman, M, et al.Carbapenem-resistant Escherichia coli harboring Klebsiella pneumoniae carbapenemase β-lactamases associated with long-term care facilities. Clin Infect Dis 2008;46:e127130.Google Scholar