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Antimicrobial Activity of Home Disinfectants and Natural Products Against Potential Human Pathogens

Published online by Cambridge University Press:  02 January 2015

William A. Rutala ,
Susan L. Barbee ,
Newman C. Aguiar ,
Mark D. Sobsey  and
David J. Weber
William A. Rutala*
Affiliation:
Division of Infectious Diseases, University of North Carolina (UNC) School of Medicine, UNC School of Public Health, Chapel Hill, North Carolina Department of Hospital Epidemiology, UNC Hospitals, UNC School of Public Health, Chapel Hill, North Carolina
Susan L. Barbee
Affiliation:
Departments of Environmental Sciences, UNC School of Public Health, Chapel Hill, North Carolina
Newman C. Aguiar
Affiliation:
Departments of Environmental Sciences, UNC School of Public Health, Chapel Hill, North Carolina
Mark D. Sobsey
Affiliation:
Departments of Environmental Sciences, UNC School of Public Health, Chapel Hill, North Carolina
David J. Weber
Affiliation:
Division of Infectious Diseases, University of North Carolina (UNC) School of Medicine, UNC School of Public Health, Chapel Hill, North Carolina Department of Hospital Epidemiology, UNC Hospitals, UNC School of Public Health, Chapel Hill, North Carolina Epidemiology, UNC School of Public Health, Chapel Hill, North Carolina
*
′547 Burnett-Womack Bldg, CB 7030, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7030
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Abstract

Objective:

To assess the efficacy of both natural products (vinegar, baking soda) and common commercial disinfectants (Vesphene Ilse, TBQ, Clorox, Lysol Disinfectant Spray, Lysol Antibacterial Kitchen Cleaner, Mr. Clean Ultra, ethanol) designed for home or institutional use against potential human pathogens, including selected antibiotic-resistant bacteria.

Design:

A quantitative suspension test was used to assess the efficacy of selected disinfectants following exposure times of 30 seconds and 5 minutes. Activity was assessed against Staphylococcus aureus, Salmonella choleraesuis, Escherichia coli 0157:H7, and Pseudomonas aeruginosa. Selected disinfectants were also tested against poliovirus, vancomycin-susceptible and -resistant Enterococcus species, and methicillin-susceptible and -resistant S aureus.

Results:

The following compounds demonstrated excellent antimicrobial activity (>5.6-8.2 log10 reduction) at both exposure times: TBQ, Vesphene, Clorox, ethanol, and Lysol Antibacterial Kitchen Cleaner. Mr. Clean eliminated 4 to >6 logs10 and Lysol Disinfectant ~4 logs10 of pathogenic microorganisms at both exposure times. Vinegar eliminated <3 logs10 of S aureus and E coli, and baking soda <3 logs10 of all test pathogens. All tested chemical disinfectants completely inactivated both antibiotic-resistant and -susceptible bacteria at both exposure times. Only two disinfectants, Clorox and Lysol, demonstrated excellent activity (>3 log10 reduction) against poliovirus.

Conclusions:

A variety of commercial household disinfectants were highly effective against potential bacterial pathogens. The natural products were less effective than commercial household disinfectants. Only Clorox and Lysol disinfectant were effective against poliovirus

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 21 , Issue 1 , January 2000 , pp. 33 - 38
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2000

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References

1.Institute of Medicine. In: Lederberg, J, Shope, RE, Oaks, SC Jr, eds. Emerging Infections: Microbial Threats to Health in the United States. Washington, DC: National Academy Press; 1992.Google Scholar
2.Emori, TG, Gaynes, RP. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin Microbiol Rev 1993;6:428–442.Google Scholar
3.Boyce, JM. Methicillin-resistant Staphylococcus aureus in hospitals and long-term care facilities: microbiology, epidemiology, and preventive measures. Infect Control Hosp Epidemiol 1992;13:725–737.Google Scholar
4.Mulligan, ME, Murray-Leisure, KA, Ribner, BS, Standiford, HC, John, JF, Korvick, JA, et al. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. Am JMed 1993;94:313–328.Google ScholarPubMed
5.Boyce, JM, Jackson, MM, Pugliese, G, Batt, MD, Fleming, D, Garner, JS, et al. Methicillin-resistant Staphylococcus aureus (MRSA): a briefing for acute care hospitals and nursing facilities, Infect Control Hosp Epidemiol 1994;15:105–115.Google Scholar
6.Weber, DJ, Rutala, WA. Role of environmental contamination in the transmission of vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 1997;18:306–309.CrossRefGoogle ScholarPubMed
7.Bonten, MJ, Hayden, MK, Nathan, C, van Voorhis, J, Matushek, M, Slaughter, S, et al. Epidemiology of colonisation of patients and environment with vancomycin-resistant enterococci. Lancet 1996;348:1615–1619.Google Scholar
8.Samore, MH, Venkataraman, L, DeGirolami, PC, Arbeit, RD, Karchmer, AW. Clinical and molecular epidemiology of sporadic and clustered cases of nosocomial Clostridium difficile diarrhea. Am J Med 1996;100:32–40.Google Scholar
9.Fekety, R, Kim, KH, Brown, D, Batts, DH, Cudmore, M, Silva, J. Epidemiology of antibiotic-associated colitis: isolation of Clostridium difficile from the hospital environment. Am JMed 1981;70:906–908.Google ScholarPubMed
10.Malamou-Ladas, H, O'Farrell, S, Nash, JQ, Tabaqchali, S. Isolation of Clostridium difficile from patients and the environment of hospital wards. J Clin Pathol 1983;36:88–92.CrossRefGoogle ScholarPubMed
11.Kaatz, GW, Gitlin, SD, Schaberg, DRWilson, KH, Kauffman, CA, Seo, SM, et al. Acquisition of Clostridium difficile from the hospital environment. Am J Epidemiol 1988;127:1289–1294.CrossRefGoogle ScholarPubMed
12.Laborde, DJ, Weigle, KA, Weber, DJ, Kotch, JB. Effect of fecal contamination on diarrheal illness rates in day-care centers. Am J Epidemiol 1993;138:243–255.CrossRefGoogle ScholarPubMed
13.Ekanem, EE, DuPont, HL, Pickering, LK, Selwyn, BJ, Hawkins, CM. Transmission dynamics of enteric bacteria in day-care centers. Am J Epidemiol 1983;118:562–572.CrossRefGoogle ScholarPubMed
14.Finch, JE, Prince, J, Hawksworth, M. A bacteriologie survey of the domestic environment. J Applied Bacteriol 1978;45:357–364.Google Scholar
15.Scott, E, Bloomfield, SF, Barlow, CG. An investigation of microbial contamination in the home. J Hyg Camb 1982;89:279–293.CrossRefGoogle ScholarPubMed
16.Gwaltney, JM Jr, Hendley, JO. Transmission of experimental rhinovirus infection by contaminated surfaces. Am J Epidemiol 1982;116:828–833.Google Scholar
17.Ward, RL, Bernstein, DI, Knowlton, DR, Sherwood, JR, Young, EC, Cusack, TM, et al. Prevention of surface-to-human transmission of rotaviruses by treatment with disinfectant spray. J Clin Microbiol 1991;29:1991–1996.CrossRefGoogle ScholarPubMed
18.Sattar, SA, Springthorpe, VS. Transmission of viral infections through animate and inanimate surfaces and infection control through chemical disinfection. In: Hurst, DJ, ed. Modeling Disease Transmission and Its Prevention by Disinfection. Cambridge, England: Cambridge University Press; 1996:224–257.Google Scholar
19.Scott, E, Bloomfield, SF. The survival and transfer of microbial contamination via cloths, hands and utensils. J Bacteriol 1990;68:271–278.Google ScholarPubMed
20.Sattar, SA, Jacobsen, H, Springthorpe, VS, Cusack, TM, Rubino, JR. Chemical disinfection to interrupt transfer of rhinovirus type 14 from environmental surfaces to hands. Appl Environ Microbiol 1993;59:1579–1585.CrossRefGoogle ScholarPubMed
21.Centers for Disease Control and Prevention. CDC Surveillance Summaries. MMWR 1996;45(SS-5):1–66.Google Scholar
22.Rutala, WA, Weber, DJ. Environmental issues and nosocomial infections. In: Farber, BF, ed. Infection Control in Intensive Care. New York, NY: Churchill Livingstone; 1987:131–171.Google Scholar
23.Griffin, PM, Boyce, TG. Escherichia coli 0157:H7. In: Scheid, WM, Armstrong, D, Hughes, JM, eds. Emerging Infections. Washington, DC: ASM Press; 1998:137–145.Google Scholar
24.Whittam, TS, McGraw, EA, Reid, SD. In: Krause, RM, ed. Emerging Infections. San Diego, CA: Academic Press; 1998:163–183.CrossRefGoogle Scholar
25.Slutsker, L, Villarino, ME, Jarvis, WR, Goulding, J. Foodborne disease prevention in healthcare facilities. In: Bennett, JV, Brachman, PS, eds. Hospital Infections. 4th ed. Philadelphia, PALippincott-Raven; 1998:333–337.Google Scholar
26.Chatburn, RL, Kallstrom, TJ, Bajaksouzian, S. A comparison of acetic acid with a quaternary ammonium compound for disinfection of hand-held nebulizers. Respir Care 1988;33:179–187.Google Scholar
27.Olson, W, Vesley, D, Bode, M, Dubbel, P, Bauer, T. Hard surface cleaning performance of six alternative household cleaners under laboratory conditions. J Environ Health 1994;56:27–31.Google Scholar
28.Bauer, JM, Beronio, CA, Rubino, JR. Antibacterial activity of environmentally “green” alternative products tested in standard antimicrobial tests and a simulated in-use assay. J Environ Health 1995;57:13–18.Google Scholar
29.Parnes, CA. Efficacy of sodium hypochlorite bleach and “alternative” products in preventing transfer of bacteria to and from inanimate surfaces. J Environ Health 1997;59:14–20.Google Scholar
30.Daschner, F. The hospital and pollution: Role of the hospital epidemiologist in protecting the environment. In: Wenzel, RP, ed. Prevention and Control of Nosocomial Infections. 3rd ed. Baltimore, MD: Williams & Wilkins; 1997:595–605.Google Scholar
31.Rutala, WA, Stiegel, MM, Sarubbi, FA, Weber, DJ. Susceptibility of antibiotic-susceptible and antibiotic-resistant hospital bacteria to disinfectants. Infect Control Hosp Epidemiol 1997;18:417–421.CrossRefGoogle ScholarPubMed
32.Anderson, RL, Carr, JH, Bond, WW, Favero, MS. Susceptibility of vancomycin-resistant enterococci to environmental disinfectants. Infect Control Hosp Epidemiol 1997;18:195–199.Google Scholar
33.Preventing the spread of vancomycin resistance—a report from the Hospital Infection Control Practices Advisory Committee prepared by the Subcommittee on Prevention and Control of Antimicrobial Resistant Microorganisms in Hospitals; comment period and public meeting— CDC. Notice. Fed Regist 1994;59:25758–25763.Google Scholar
34.Garner, JS. Guideline for isolation precautions in hospitals. Infect Control Hosp Epidemiol 1996;17:53–80.CrossRefGoogle ScholarPubMed
35.Occupational Exposure to Bloodborne pathogens—OSHA Final rule. Fed Regist 1991;56:64175–64182.Google Scholar
36.Rutala, WA. APIC guideline for selection and use of disinfectants. Am J Infect Control 1996;24:313–342.Google Scholar
37.Kotch, JB, Weigle, KA, Weber, DJ, Clifford, RM, Harms, TO, Loda, FA, et al. Evaluation of an hygienic intervention in day-care centers. Pediatrics 1994;94:991–994.Google Scholar
38.Sattar, SAJacobsen, H, Rahman, H, Cusack, TM, Rubino, JR. Interruption of rotavirus spread through chemical disinfection. Infect Control Hosp Epidemiol 1994;15:751–756.Google Scholar