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Infection of the choroid plexus by feline immunodeficiency virus

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Abstract

The human, simian, and feline immunodeficiency viruses rapidly penetrate into the brain and trigger an inflammatory process that can lead to significant neurologic disease. However, the mechanisms that permit efficient trafficking of macrophage-tropic and the more neurotoxic lymphocytotropic isolates are still poorly understood. One potential source of virus entry may be the blood-CSF barrier provided by the choroid plexus. Infected cells are often detected within the choroid plexus but it is unclear whether this reflects trafficking cells or infection of the large macrophage population within the choroidal stroma. To address this issue, we cultured fetal feline choroid plexus and evaluated the ability of feline immunodeficiency virus (FIV) to establish a primary infection. Significant provirus was detected in macrophage-enriche d choroid plexus cultures as well as in the choroid plexus of cats infected in vivo. FIV p24 antigen production in vitro was very low but detectable. Addition of a feline T-cell line to macrophages inoculated with FIV resulted in a dense clustering of the T cells over macrophages with dendritic cell-like morphologies and a robust productive infection. The direct infection of choroid plexus macrophages with FIV, the efficient transfer of the infection to T cells indicate that the choroid plexus can be a highly efficient site of viral infection and perhaps trafficking of both macrophage-tropic and T-cell-tropic viruses into the CNS.

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  1. D. C. Bragg

    Present address: Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts

Authors and Affiliations

  1. Neurobiology Curriculum and Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA

    D. C. Bragg & R. B. Meeker

  2. Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

    R. B. Meeker

  3. Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

    T. A. Childers, M. B. Tompkins & W. A. Tompkins

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  1. D. C. Bragg
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  2. T. A. Childers
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  4. W. A. Tompkins
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  5. R. B. Meeker
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Correspondence to R. B. Meeker.

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This work was supported by Public Health Service Grant NS33408 from the National Institute of Neurological Disorders and Stroke and the UNC Center for AIDS Research 9P30 AI50410.

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Bragg, D.C., Childers, T.A., Tompkins, M.B. et al. Infection of the choroid plexus by feline immunodeficiency virus. Journal of NeuroVirology 8, 211–224 (2002). https://doi.org/10.1080/13550280290049688

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