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CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes

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Abstract

Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeficiency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1α (SDF-1α), SDF-1β, or the bicyclam AMD3100 in a dose-dependent manner. These observations suggest that, like FIV infection in CrFK cells and lymphocytes, the virus uses CXCR4 as a primary receptor for infecting astrocytes and this can be a possible natural model for AIDS dementia complex.

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Authors and Affiliations

  1. National Institute of Neuroscience, NCNP Kodaira, Tokyo

    Keiko Nakagaki, Keikichi Takahashi & Takeshi Tabira

  2. Nippon Jui Chikusan University, Musashino, Tokyo, Japan

    Kazuhide Nakagaki

  3. Rega Institute for Medical Research, Leuven, Belgium

    Dominique Schols & Erik De Clercq

Authors
  1. Keiko Nakagaki
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  2. Kazuhide Nakagaki
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  3. Keikichi Takahashi
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  4. Dominique Schols
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  5. Erik De Clercq
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  6. Takeshi Tabira
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Correspondence to Takeshi Tabira.

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Nakagaki, K., Nakagaki, K., Takahashi, K. et al. CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes. Journal of NeuroVirology 7, 487–492 (2001). https://doi.org/10.1080/135502801753170354

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  • DOI: https://doi.org/10.1080/135502801753170354

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