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Iron, infection and immune function

Published online by Cambridge University Press:  28 February 2007

Chaim Hershko
Chaim Hershko
Affiliation:
Department of Medicine, Shaare Zedek Medical Center and Department of Nutrition, Hebrew University Hadassah Medical School, PO Box 293, Jerusalem, Israel
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Abstract

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Type
Symposium on ‘Functional significance of micronutrient undernutrition’
Information
Proceedings of the Nutrition Society , Volume 52 , Issue 1 , February 1993 , pp. 165 - 174
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Ampel, N. M., Van Wyck, D. B., Aquirre, M. L., Willis, D. G. & Popp, R. A. (1989). Resistance to infection in murine beta-thalassemia. Infection and Immunity 57, 1011–1017.Google Scholar
Andelman, M. B. & Sered, B. R. (1966). Utilization of dietary iron by term infants: A study of 1048 infants from a low socioeconomic population. American Journal of Disease in Children 111, 45–55.CrossRefGoogle Scholar
Barry, D. M. J. & Reeve, A. W. (1977). Increased incidence of gram-negative neonatal sepsis with intramuscular iron administration. Pediatrics 60, 908–912.Google Scholar
Barry, D. M. J. & Reeve, A. W. (1988). Iron and infection. British Medical Journal 296, 1736.CrossRefGoogle ScholarPubMed
Brock, J. H. & Mainou-Fowler, T. (1983). The role of iron and transferrin in lymphocyte transformation. Immunology Today 4, 347–351.Google Scholar
Bullen, A. W. & Losowsky, M. S. (1979). Consequences of impaired splenic function. Clinical Science 57, 129–137.Google Scholar
Burman, D. (1972). Hemoglobin levels in normal infants aged 3–24 months and the effect of iron. Archives of Disease in Childhood 47, 261–271.Google Scholar
Byles, A. B. & D'sa, A. (1970). Reduction of reaction due to iron dextran infusion using chloroquine. British Medical Journal 3, 625–627.Google Scholar
Byrd, T. F. & Horwitz, M. A. (1989). Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. Journal of Clinical Investigation 83, 1457–1465.Google Scholar
Cantinieaux, B., Hariga, C., Ferster, A., De Maertelaere, E., Toppet, M. & Fondu, P. (1987). Neutrophil dysfunctions in thalassaemia major: the role of cell iron overload. European Journal of Haematology 39, 28–34.Google Scholar
Cantwell, R. J. (1972). Iron deficiency anaemia in infancy. Clinical Pediatrics 11, 443–449.Google Scholar
Clarkson, A. B., Saric, M. & Grady, R. W. (1990). Deferoxamine and eflornitine (DF-α-difluoromethyl-ornithine) in a rat model of Pneuniocystis carinii pneumonia. Antimicrobial Agents and Chemotherapy 34, 1833–1835.Google Scholar
Crosa, J. H. (1984). The relationship of plasmid mediated iron transport and bacterial virulence. Annual Review of Microbiology 38, 69–89.Google Scholar
Dallman, P. R. (1987). Iron deficiency and the immune response. American Journal of Clinical Nutrition 46, 329–334.CrossRefGoogle ScholarPubMed
Damsdaran, M., Naidu, A. N. & Sarma, K. V. R. (1979). Anemia and morbidity in rural preschool children. Indian Journal of Medical Research 69, 448–456.Google Scholar
Dhur, A., Galan, P. & Hercberg, S. (1989). Iron status, immune capacity and resistance to infections. Comparative Biochemistry and Physiology 94, 11–19.Google Scholar
Dinarello, C. A. (1984). Interleukin-1. Review of Infectious Diseases 6, 51–95.Google Scholar
Finch, S. C. & Finch, C. A. (1955). Idiopathic hemochromatosis, an iron storage disease. Medicine 34, 381–430.CrossRefGoogle ScholarPubMed
Fritsch, G., Sawatzki, G., Treumer, J., Jung, A. & Spira, D. T. (1987). Plasmodium falciparum: Inhibition in vitro with lactoferrin, desferrithiocin, and desferricrocin. Experimental Parasitology 63, 1–9.Google Scholar
Fritsch, G., Treumer, J., Spira, D. T. & Jung, A. (1985). Plasmodium vinckei: suppression of mouse infections with desferrioxamine B. Experimental Parasitology 60, 171–174.CrossRefGoogle ScholarPubMed
Good, M. F., Powell, L. W. & Halliday, J. W. (1988). Iron status and cellular immune competence. Blood Reviews 2, 43–49.CrossRefGoogle ScholarPubMed
Gordeuk, V. R., Thuma, P. E., Brittenham, G. M., Zulu, S., Simwanza, G., Mhangu, A., Flesch, G. & Parry, D. (1992). Iron chelation with deferoxamine B in adults with asymptomatic Plasmodium falciparum parasitemia. Blood 79, 308–312.Google Scholar
Harvey, P. W., Heywood, P. F., Nesheim, M. C., Galme, K., Zegans, M., Habicht, J. P., Stephenson, L. S., Radimer, K. L., Brabin, B. & Forsyth, K. (1989). The effect of iron therapy on malarial infection in Papua New Guinean schoolchildren. American Journal of Tropical Medicine and Hygiene 40, 12–18.CrossRefGoogle Scholar
Hershko, C. & Peto, T. E. A. (1988). Deferoxamine inhibition of malaria is independent of host iron status. Journal of Experimental Medicine 168, 375–387.Google Scholar
Hershko, C., Peto, T. E. A. & Weatherall, D. J. (1988). Regular review. Iron and infection. British Medical Journal 296, 666–667.CrossRefGoogle Scholar
Hershko, C., Theanacho, E. N., Spira, D. T., Peter, H. H., Dobbin, P. & Hider, R. C. (1991). The effect of N-alkyl modification on the antimalarial activity of 3-hydroxypyrid-4-one oral iron chelators. Blood 77, 637–643.Google Scholar
Hilgartner, M. W. & Grady, R. W. (1986). Decreased natural killer activity in thalassemia major: a possible consequence of iron overload. Journal of Immunology 136, 1635–1640.Google Scholar
Hoffbrand, A. V., Ganeshaguru, K., Hooton, J. W. L. & Tattersall, M. H. N. (1976). Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells. British Journal of Haematology 33, 517–526.CrossRefGoogle ScholarPubMed
Kochan, I. (1973). The role of iron in bacterial infections with special consideration of host-tubercle bacillus interaction. Current Topics in Microbiology and Immunology 60, 1–30.Google Scholar
Konijn, A. M. & Hershko, C. (1977). Ferritin synthesis in inflammation: 1. Pathogenesis of impaired iron release. British Journal of Haematology 37, 7–16.Google Scholar
Lalonde, R. G. & Holbein, B. E. (1986). Role of iron in Trypanosoma crzi infection in mice. Journal of Clinical Investigation 73, 470–476.CrossRefGoogle Scholar
Lane, T. E., Wu-Hsieh, B. A. & Howard, D. H. (1991). Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages. Infection and Immunity 59, 2274–2278.Google Scholar
Mackay, H. M. (1928). Anemia in infancy: its prevalence and prevention. Archives of Disease in Childhood 3, 117–147.Google Scholar
Masawe, A. E. J. & Nsanzumhire, H. (1973). Growth of bacteria in vitro in blood from patients with severe iron deficiency anemia and from patients with sickle cell anemia. American Journal of Clinical Pathology 59, 706–711.CrossRefGoogle ScholarPubMed
Modell, B. & Berdoukas, V. (1984). The Clinical Approach to Thalassaemia. London: Grune and Stratton.Google Scholar
Murakawa, H., Bland, C. E., Willis, W. T. & Dallman, P. R. (1987). Iron deficiency and neutrophil function: different rates of correction of the depressions in oxidative burst and myeloperoxidase activity after iron treatment. Blood 69, 1464–1468.Google Scholar
Murray, M. J., Murray, A. B., Murray, M. B. & Murray, C. J. (1978). The adverse effect of iron repletion on the course of certain infections. British Medical Journal 2, 1113–1115.Google Scholar
Neilands, J. B. (1981). Microbial iron compounds. Annual Review of Biochemistry 50, 715–731.Google Scholar
Oppenheimer, S. J., Gibson, F. D. & McFarlane, S. B. (1986). Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Transcripts of Royal Society of Tropical Medicine and Hygiene 80, 603–612.CrossRefGoogle ScholarPubMed
Payne, S. M. (1988). Iron and virulence in the family of Enterobacteriaceae. Critical Reviews in Microbiology 16, 81–111.Google Scholar
Pollack, S., Rossan, R. N., Davidson, D. E. & Escajadillo, A. (1987). Desferrioxamine suppresses Plasmodium fakiparum in aotus monkeys. Proceedings of the Society of Experimental Biology and Medicine 184, 162–165.CrossRefGoogle ScholarPubMed
Schryvers, A. B. & Gonzalez, G. C. (1989). Comparison of the abilities of different protein sources of iron to enhance Neisseria meningitidis infection in mice. Infection and Immunity 57, 2425–2429.CrossRefGoogle ScholarPubMed
Segovia, M., Navarro, A. & Artero, J. M. (1989). The effect of liposome-entrapped desferrioxamine on Leishmania donovani in vitro. Annals of Tropical Medicine and Parasitology 83, 357–360.CrossRefGoogle ScholarPubMed
Seifert, A., von Herrath, D. & Schaefer, K. (1987). Iron overload, but not treatment with desferrioxamine favours the development of septicemia in patients on maintenance hemodialysis. Quarterly Journal of Medicine 65, 1015–1024.Google Scholar
Smith, C. H., Erlandson, M. E., Stern, G. & Hilgartner, M. W. (1964). Post splenectomy infection in Cooley's anemia. Annals of New York Academy of Sciences 119, 748–758.Google Scholar
Sokol, P. A. (1987). Surface expression of ferripyochelin-binding protein is required for virulence of Pseudomonas aeruginosa. Infection and Immunity 55, 2021–2025.CrossRefGoogle ScholarPubMed
Sussman, M. (1974). Iron and infection. In Iron in Biochemistry and Medicine, pp. 649–679 [Jacobs, A. & Worwood, M., editors]. New York: Academic Press.Google Scholar
Tielemans, C. L., Lenclud, C. M., Wens, R., Collart, F. E. & Dratwa, M. (1989). Critical role of iron overload in the increased susceptibility of haemodialysis patients to bacterial infections. Beneficial effects of desferrioxamine. Nephrology Dialysis and Transplantation 4, 883–887.CrossRefGoogle ScholarPubMed
Walter, T., Arredondo, S., Arevalo, M. & Stekel, A. (1986). Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants. American Journal of Clinical Nutrition 44, 877–882.CrossRefGoogle Scholar
Waterlot, Y., Cantinieaux, B., Hariga-Muller, C., DeMaertelaere-Laurent, C., Vanherweghem, J. L. & Fondu, P. (1985). Impaired phagocytic activity of neutrophils in patients receiving haemodialysis: the critical role of iron overload. British Medical Journal 291, 501–504.Google Scholar
Weinberg, E. D. (1990). Cellular iron metabolism in health and disease. Drug Merabolkm Reviews 22, 531–579.CrossRefGoogle ScholarPubMed
Yinnon, A. M., Theanacho, E. N., Grady, R. W., Spira, D. Y. & Hershko, C. (1989). Antimalarial effect of HBED and other phenolic and catecholic iron chelators. Blood 74, 2166–2171.Google Scholar