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Metabolic response to small and large 13C-labelled pasta meals following rest or exercise in man

Published online by Cambridge University Press:  09 March 2007

Nathalie Folch ,
François Péronnet ,
Denis Massicotte ,
Martine Duclos ,
Carole Lavoie  and
Claude Hillaire-Marcel
Nathalie Folch
Affiliation:
Département de kinésiologie, Université de Montréal, CP 6128 Centre-Ville, Montréal, Québec H3C 3J7, Canada
François Péronnet*
Affiliation:
Département de kinésiologie, Université de Montréal, CP 6128 Centre-Ville, Montréal, Québec H3C 3J7, Canada
Denis Massicotte
Affiliation:
Département de kinanthropologie and Laboratoire de géochimie isotopique et de géochronologie, Université du Québec à Montréal, Montréal, Québec H3C 3P8, Canada
Martine Duclos
Affiliation:
Laboratoire Neurogénétique et stress, INSERM U471, Institut François Magendie, rue Camille Saint Sëns, 33077 Bordeaux cedex, France
Carole Lavoie
Affiliation:
Université du Québec à Trois-Rivières, Trois-Rivières, Québec G9A 5H7, Canada
Claude Hillaire-Marcel
Affiliation:
Département de kinanthropologie and Laboratoire de géochimie isotopique et de géochronologie, Université du Québec à Montréal, Montréal, Québec H3C 3P8, Canada
*
*Corresponding author: François Péronnet, fax +1 514 343 2181, email francois.peronnet@umontreal.ca
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Abstract

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The metabolic response to a 150 or 400 g 13C-labelled pasta meal was studied for 8 h following rest or exercise at low or moderate workload (n 6). Following rest, the 400 g meal totally suppressed fat oxidation (v. 14.1 g following the 150 g meal) and a small amount of glucose was converted into fat (4.6 g), but fat oxidation remained high in subjects who had exercised following both the small (21.8 and 34.1 g) and large meal (14.1 and 32.3 g). Exogenous glucose oxidation was significantly higher in subjects who had remained at rest both following the small (67.6 g v. 60.4 and 51.3 g in subjects who exercised at low and moderate workloads) and large meal (152.2 v. 123.0 and 127.2 g). Endogenous glucose oxidation was similar in the three groups following the 150 g meal (42.3–58.0 g), but was significantly lower following the 400 g meal in subjects who had exercised at low workload (24.2 v. 72.2 g following rest; P<0.05), and was totally suppressed in those who had exercised at moderate workload. As a consequence, a larger positive glycogen balance was observed in subjects who exercised before the large meal (182.8–205.1 g v. 92.4 g following rest; P<0.05). Total fat oxidation calculated from 08.00 hours to 20.00 hours was similar in subjects who exercised at low and moderate workloads. These results indicate that: (1) de novo lipogenesis, which plays only a minor role for the disposal of an acute dietary carbohydrate load, is totally suppressed following exercise, even when a very large carbohydrate load is ingested; (2) the reduction in glycogen turnover as well as a preferential conversion of glucose into glycogen are responsible for the increase in glycogen stores following exercise; (3) for a similar energy expenditure, exercise at low workload for a longer period does not favour fat oxidation when the post-exercise period is taken into account.

Keywords

Stable isotopeDe novo lipogenesisGlycogen stores
Type
Research Article
Information
British Journal of Nutrition , Volume 85 , Issue 6 , May 2001 , pp. 671 - 680
Copyright
Copyright © The Nutrition Society 2001

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