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In vitro lipid metabolism, growth and metabolic hormone concentrations in hyperthyroid chickens*

Published online by Cambridge University Press:  09 March 2007

R. W. Rosebrough ,
J. P. McMurtry  and
R. Vasilatos-Younken
R. W. Rosebrough
Affiliation:
Nonruminant Animal Nutrition Laboratory, Livestock and Poultry Science Institute, United States Department of Agriculture–Agricultural Research Service, Beltsville Agricultural Research Center, Beltsville, MD 20705, USA
J. P. McMurtry
Affiliation:
Nonruminant Animal Nutrition Laboratory, Livestock and Poultry Science Institute, United States Department of Agriculture–Agricultural Research Service, Beltsville Agricultural Research Center, Beltsville, MD 20705, USA
R. Vasilatos-Younken
Affiliation:
Department of Poultry Science, The Pennsylvania State University, University Park, PA 16802, USA
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Abstract

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Indian River male broiler chickens growing from 7 to 28 d of age were fed on diets containing energy: protein values varying from 43 to 106 MJ/kg protein and containing 0 or 1 mg triiodothyronine (T3)/kg diet to study effects on growth, metabolic hormone concentrations and in vitro lipogenesis. In vitro lipid synthesis was determined in liver explants in the presence and absence of ouabain (Na+, K+-transporting ATPase (EC 3.6.1.37) inhibitor) to estimate the role of enzyme activity in explants synthesizing lipid. Growth and feed consumption increased (P < 0.01) when the energy: protein value decreased from 106 to 71 MJ/kg protein; however, both variables decreased as the value was further decreased from 53 to 43 MJ/kg protein. Triiodothyronine depressed (P < 0.01) growth, but not food intake. Large energy:protein diets (> 53 MJ/kg protein) and dietary T3 lowered (P < 0.01) plasma growth hormone. Large energy:protein diets (> 53 MJ/kg protein) increased (P < 0.01) lipogenesis, plasma growth hormone (GH) and decreased plasma insulin-like growth factor 1 (IGF-1). Also, T3 decreased plasma GH, IGF-1 in vitro lipogenesis. Ouabain inhibited a greater proportion of in vitro lipogenesis in those explants synthesizing fat at a high rate. Both dietary T3 and in vitro ouabain decrease lipogenesis, but, when combined, the effects are not cumulative

Keywords

LipogenesisDietary proteinATPaseThyroid hormonesChickens
Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 3 , November 1992 , pp. 667 - 676
Copyright
Copyright © The Nutrition Society 1992

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