Effects of Pentoxifylline on Inflammatory Cytokine Expression and Acute Pleuropneumonia in Swine
References (47)
The proper use and benefits of veterinary antimicrobial agents in swine practice
Vet. Microbiol.
(1993)- et al.
Inflammatory cytokines in animal health and disease. Vet.
Immunol. Immunopathol.
(1996) - et al.
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Anal. Biochem.
(1987) - et al.
Inhibition of tumor necrosis factor-α (TNF–α) and interleukin–1β (IL-1β) messenger RNA (mRNA) expression in HL–60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin–induced TNF–α and IL- 1β mRNA expression from acivicin–induced monocytoid differentiation
Blood
(1992) - et al.
The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL–6), and tumor necrosis factor (TNF) in the rat
Cytokine
(1990) - et al.
Differential effects of pentoxifylline, a non-specific phosphodiesterase inhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages
Immunopharmacology
(2000) - et al.
Pharmacokinetics of orally administered pentoxifylline in humans
J. Pharm. Sci.
(1986) - et al.
Infection of macrophages by influenza A virus: characterization of tumour necrosis factor–alpha (TNF–alpha) gene expression
Res. Virol.
(1996) - et al.
Involvement of 26-kDa membrane-bound tumour necrosis factor precursor in bidirectional feedback regulation on 17-kDa tumour necrosis factor production after stimulation by lipopolysaccharide
Cytokine
(1998) - et al.
Noncleavable transmembrane mouse tumor necrosis factor-a (TNF-α) mediates effects distinct from those of wild-type TNF-α in vitro and in vivo
J. Biol. Chem.
(1999)
Actinobacillus pleuropneumoniae
Actinobacillus (Haemophilus) pleuropneumoniae. Part I. history, epidemiology, serotyping, and treatment
Compend Cont Educ
Pulmonary lesions in mice inoculated with Actinobacillus pleuropneumoniae hemolysin and lipopolysaccharide
Vet. Pathol.
Role of Haemophilus pleuropneumoniae lipopolysaccharide endotoxin in the pathogenesis of porcine Haemophilus pleuropneumonia
Am. J. Vet. Res.
Inflammatory cytokine expression in swine experimentally infected with Actinobacillus pleuropneumoniae
Infect. Immun.
Pathophysiological correlates of acute porcine pleuropneumonia
Amer. J. Vet. Res.
Interleukin–10 gene therapy-mediated amelioration of bacterial pneumonia
Infect. Immun.
Group B Streptococcus induces tumor necrosis factor in neonatal pigs. Effect of the tumor necrosis factor inhibitor pentoxifylline on hemodynamics and gas exchange
Am. Rev. Respir. Dis.
Early post-treatment with pentoxifylline or dibutyryl cAMP attenuates Escherichia coli-induced acute lung injury in guinea pigs
Am. Rev. Respir. Dis.
Pharmacology of pentoxifylline, a hemorrheologic agent for the treatment of intermittent claudication
Angiology
ARDS, neutrophils, and pentoxifylline
Am. Rev. Respir. Dis.
Attenuation of acute lung injury in septic guinea pigs with pentoxifylline
Am. Rev. Respir. Dis.
Increase of survival rate by pentoxifylline in endotoxic shock
Cited by (15)
Infection dynamics and acute phase response of an Actinobacillus pleuropneumoniae field isolate of moderate virulence in pigs
2014, Veterinary MicrobiologyCitation Excerpt :Previous studies of other swine respiratory diseases have reported a marked expression of pro-inflammatory cytokines only at the lung level without significant changes in their serum concentrations, making it necessary to examine samples from the lung parenchyma to determine the events occurring in the respiratory tracts of infected pigs (Gómez-Laguna et al., 2013). Thus, according to previous in vitro (Myers et al., 2002; Benga et al., 2009; Chen et al., 2011) and in vivo (Baarsch et al., 2000; Benga et al., 2009) studies, IL-1β and/or to a lesser extent TNF-α might be expressed at the lung level displaying a paracrine effect in the onset of lung lesions in PCP. Our results affirm the role of IL-6 in the induction of an acute phase response after Ap6 infection.
Advances in swine immunology help move vaccine technology forward
2014, Veterinary Immunology and ImmunopathologyCitation Excerpt :The general molecular features of innate anti-viral and anti-bacterial responses that have been elucidated primarily in murine host–pathogen models provide useful models for investigation of host defense in veterinary species. In swine, for example, respiratory infection by the gram-negative bacteria, Actinobacillus pleuropneumoniae, induces an acute, robust lung cytokine response characterized by IL-1, IL-6 and IL-8 production (Baarsch et al., 1995, 2000; Morrison et al., 2000; Myers et al., 2002; Van Reeth et al., 2002). However, despite the presence of bacterial LPS and CpG DNA, there is no induction in vivo of tumor necrosis factor (TNF), the classical inflammatory cytokine molecule and effector product of NF-κB activation, even though in vitro incubation of alveolar macrophages with boiled extracts of A. pleuropneumoniae readily induces TNF (Baarsch et al., 1995, 2000).
In vitro down regulation of proinflammatory cytokines induced by LPS tolerance in pig CD14+ cells
2006, Veterinary Immunology and ImmunopathologyThe combination of PRRS virus and bacterial endotoxin as a model for multifactorial respiratory disease in pigs
2004, Veterinary Immunology and ImmunopathologyCitation Excerpt :Pentoxifylline can inhibit neutrophil adhesion and activation, improve blood perfusion and cause bronchodilatation (Tighe et al., 1990; Cortijo et al., 1993). Myers et al. (2002) studied the effect of pentoxifylline on acute pleuropneumonia caused by A. pleuropneumoniae in swine. They found that a dose of 20 mg/kg s.c. had no effect on the expression of proinflammatory cytokines in the lungs.
A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19
2022, Inflammopharmacology