Molecular & Cellular Proteomics
ResearchCancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway*,
Graphical Abstract
Highlights
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Quantitative proteomics analysis of cancer cell derived small extracellular vesicles (sEVs) reveals metastasis related proteins.
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HGF/c-Met signaling pathway is mainly activated by cancer cell-secreted sEVs-HGF.
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sEVs-HGF plays essential role in the metastasis of cancer cells.
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Author contributions: Z.Q., Y.Z., M.G., and H.X. designed research; Z.Q., Y.Z., M.G., and H.X. performed research; Z.Q., Y.Z., M.G., and H.X. contributed new reagents/analytic tools; Z.Q., Y.Z., M.G., S.L., X.J., Z.S., H.L., C.C., and H.X. analyzed data; Z.Q., Y.Z., M.G., and H.X. wrote the paper.
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This work was supported by grants from the National Key Research and Development Program (No. 2017YFC1200204), the National Natural Science Foundation of China (No. 21675110, No. 21475086, No. 21305087), the Committee of Shanghai Science and Technology (No. 14DZ0501200 and No. 15142200300), and the Key Scientific Project of Shanghai Jiao Tong University (No. YG2014QN21, YG2015MS48 and YG2017MS80). H.X. is supported by the Recruitment Program of Global Youth Experts of China and National High-tech R&D Program of China (863 Program, No. 2014AA020545).
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This article contains supplemental Figures and Tables. The authors declare no competing financial interests
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These authors contributed equally as first authors to this work.