Molecular & Cellular Proteomics
ResearchIn Vivo Phosphoproteome Analysis Reveals Kinome Reprogramming in Hepatocellular Carcinoma*
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Author contributions: L.L.R. and Y.J. designed and conceived the studies; L.L.R. performed the MS studies and computational analysis; C.Y.L. performed the functional assays; Y.L.W., Y.T., and X.Y. provided the HBx-transgenic mouse liver samples; H.C.S. and B.C.X. provided the HCC and pairwise adjacent nontumor liver tissue samples; F.C.H. and Y.J. supervised the work; L.L.R., C.Y.L., Y.J., and F.C.H. wrote the manuscript; all authors proofread the manuscript. The authors declare no competing interests.
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This work was partially supported by Chinese State Key Projects for Basic Research (“973 Program”) (Nos. 2014CBA02001 and 2013CB910502), National Key Research and Development Project (2016YFC0902400), National Natural Science Foundation of China (81123001 and 81570526), Innovation project(16CXZ027), Chinese State High-tech Program (“863 Program”) (Nos. 2012AA020204 and 2014AA020906), The Program of International S&T Cooperation (2014DFB30020, 2014DFB30010), Natural Science Foundation of Beijing (7152036) and Open Project Program of the State Key Laboratory of Proteomics (Academy of Military Medical Sciences, SKLP-O201509), China Postdoctoral Science Foundation (2015M582851).
This article contains supplemental material.
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These authors contributed equally to this work.