Molecular & Cellular Proteomics
ResearchComprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components*
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Author contributions: M.J.v., M.I.Z., E.N.N., A.M.A., F.A.R., and M.H.W. designed research; M.J.v., M.I.Z., and S.G. performed research; M.J.v., S.G., and A.M.A. analyzed data; M.J.v., M.I.Z., S.G., E.N.N., J.G., B.S., A.M.A., F.A.R., and M.H.W. wrote the paper.
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This research was performed as part of project 11676 within the framework of a partnership program jointly funded by Nutricia Research and the Dutch Technology Foundation STW, which is part of the Netherlands Organization for Scientific Research (NWO), and is partly funded by the Ministry of Economic Affairs. A.F.M.A. was supported by the Netherlands Organization for Scientific Research (NWO) with a VIDI grant (723.012.102). This work is part of the project Proteins At Work, financed by the Netherlands Organisation for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands (project number 184.032.201). This work is part of the Utrecht University focus area Future Food Utrecht.
This article contains supplemental material.
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The abbreviations used are:
- MFG
Milk fat globules
- ANXAs
Annexins
- ER
Endoplasmic reticulum
- EV
Extracellular vesicles
- GO
Gene Ontology
- MFGM
Milk fat globule membrane
- RABs
Ras-related proteins.