Molecular & Cellular Proteomics
ResearchTotal Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia*[S]
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Author contributions: J.Z., N.R.K., and A.R.P. designed research; G.L.E. performed research; G.L.E., J.Z., P.V.J., N.R.K., and A.R.P. analyzed data; G.L.E., J.Z., R.E.J., K.J.T., P.V.J., N.R.K., and A.R.P. wrote the paper; R.E.J. generated MS data; K.J.T. generated migration assay data; K.L. and G.G.J. characterized clinical features of patient samples; M.O. provided patient samples and clinical data; K.P. contributed to the generation of MS data.
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This work was supported by the North West Cancer Research (UK), Leukaemia & Lymphoma Research (UK) and the Liverpool Cancer Research UK Centre Research Development Fund.
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This article contains supplemental Tables S1–S3, supplemental Figs. S1–S5, and supplemental data.
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Both authors contributed equally to this work.
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Present address: Translational Molecular Diagnostic Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.