Journal of Biological Chemistry
Volume 296, January–June 2021, 100221
Research ArticleAncestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
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Keywords
flavin-containing monooxygenase (FMO)
flavin adenine dinucleotide (FAD)
ancestral-sequence reconstruction (ASR)
NAD(P)H
enzyme kinetics
stopped flow
crystal structure
Abbreviations
AltAncFMO
alternative versions of the ancestral flavin-containing monooxygenase
AncFMO
ancestral flavin-containing monooxygenase
ASR
ancestral-sequence reconstruction
CYP
Cytochrome P450
DDM
dodecyl-β-D-maltoside
FAD
flavin adenine dinucleotide
FMO
flavin-containing monooxygenase
hFMO
human flavin-containing monooxygenase
PP
posterior probability
Tm
melting temperature
TRX
Triton X100
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© 2020 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.