Journal of Biological Chemistry
Volume 286, Issue 12, 25 March 2011, Pages 10530-10539
Protein Structure and FoldingThe Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease*
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open access
Crystal Structure
DNA Repair
DNA Replication
RNA-binding Protein
X-ray Crystallography
Aicardi-Goutières Syndrome
RNase H2
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The atomic coordinates and structure factors (codes3P5J and 3P56) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
- *
This research was funded in part by a Medical Research Council Senior Clinical Fellowship grant (to A. P. J.) and Cancer Research UK grant (to E. Y. J.). The work was also supported by the Wellcome Trust Core Award (Grant 075491/Z04).
The on-line version of this article (available at http://www.jbc.org) contains supplemental Tables S1–S3.
- 1
Both authors contributed equally to this work.
- 3
An 1851 Research Fellow.
© 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.