Journal of Biological Chemistry
Protein Synthesis and DegradationThe NADPH oxidase NOX4 promotes the directed migration of endothelial cells by stabilizing vascular endothelial growth factor receptor 2 protein
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Author contributions—K. M., S. O., A. Y., and F. K. conceptualization; K. M. and S. O. data curation; K. M., S. O., A. Y., C. K., M. K., T. K., M. Tamura, and F. K. formal analysis; K. M., S. O., C. K., M. K., T. K., M. Tamura, and F. K. funding acquisition; K. M., S. O., and C. K. investigation; K. M., S. O., A. Y., C. K., M. K., M. Tamura, M. Taura, and F. K. methodology; K. M., S. O., and M. Taura writing-original draft; K. M. and S. O. project administration; K. M., S. O., A. Y., M. K., T. K., M. Tamura, and F. K. writing-review and editing; M. Taura validation.
Funding and additional information—This study was supported in part by JSPS KAKENHI grant numbers JP17K08637 (to K. M.), JP18K07804 (to F. K.), and JP19K07676 (to A. Y.), in part by the Wesco Scientific Promotion Foundation (to K. M. and A. Y.), in part by the Ryobi Teien Memory Foundation (to K. M. and A. Y.), and in part by Research Project Grants (nos. R01S-003 (to K. M.), H30Y-002 (to S. O.), R01B-081 (to F. K.), and R01B-093 (to A. Y.)) from Kawasaki Medical School.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- ECs
endothelial cells
- VEGF
vascular endothelial growth factor
- ROS
reactive oxygen species
- ER
endoplasmic reticulum
- DPI
diphenyleneiodonium
- NAC
N-acetylcysteine
- HVA
homovanillic acid
- PI
propidium iodide
- Endo H
endoglycosidase H
- BFA
brefeldin A
- CHX
cycloheximide
- VD
velocity–directionality
- PNGase F
peptide:N-glycosidase F.
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These authors contributed equally to this work.