Journal of Biological Chemistry
Membrane BiologyThe central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability
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Author contributions—W. G., B. S., R. W., and S. W. C. conceptualization; W. G., J. P. E., and R. W. data curation; W. G. and B. S. formal analysis; W. G., B. S., and S. W. C. investigation; W. G., B. S., and R. W. methodology; W. G., R. W., and S. W. C. writing-original draft; B. S., J. P. E., and S. W. C. writing-review and editing; J. P. E. and S. W. C. project administration; S. W. C. resources; S. W. C. supervision; S. W. C. funding acquisition.
Funding and additional information—This work was supported by the Canadian Institutes of Health Research Grant PJT-155940 (to S. R. W. C.), the Heart and Stroke Foundation of Canada Grant G-19-0026444 (to S. R. W. C.), and the Heart and Stroke Foundation Chair in Cardiovascular Research (to S. R. W. C.). W. G. is a recipient of the Alberta Innovates-Health Solutions Graduate Studentship Award, and B. S. is a recipient of the Heart and Stroke Foundation of Canada Junior Fellowship Award and the AIHS Fellowship Award.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- RyR2
cardiac ryanodine receptor
- CICR
Ca2+-induced Ca2+ release
- CTD
C-terminal domain
- CPVT
catecholaminergic polymorphic ventricular tachycardia
- KRH
Krebs-Ringer-Hepes
- ANOVA
analysis of variance.