Journal of Biological Chemistry
Protein Structure and FoldingDiscovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus
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Author contributions—Q. D. and D. J. C. conceptualization; Q. D. and Q. K. data curation; Q. D., E. K. G., N. D. C., and Q. K. formal analysis; Q. D., L. Y. C., E. K. G., S. T. H., Q. K., Y-H. H., and D. J. C. investigation; Q. D. writing-original draft; L. Y. C., Q. K., Y-H. H., and D. J. C. supervision; L. Y. C., Y-H. H., E. K. G., and S. T. H. methodology; L. Y. C., E. K. G., S. T. H., N. D. C., A. S. R., Q. K., Y-H. H., and D. J. C. writing-review and editing; A. S. R. resources; D. J. C. funding acquisition; D. J. C. project administration.
Funding and additional information—This work was supported by the Australian Research Council (ARC) Grant DP150100443 (to E. K. G. and D. J. C) and National Health and Medical Research Council Grant APP1084965 (to S. T. H. and D. J. C.). This work was also supported by Advance Queensland Women's Academic Fund Grant WAF-6884942288 (to L. Y. C.). Q. D. is supported by the China Scholarship Council.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Present address for Anjaneya S. Ravipati: MWAC, Bioanalytical Mass Spectrometry Facility, The University of New South Wales, Sydney, New South Wales, Australia
Abbreviations—The abbreviations used are:
- ARC
Australian Research Council
- PE
phosphatidylethanolamine
- RP-HPLC
reversed phase HPLC
- TOCSY
total correlation spectroscopy
- kB1
kalata B1
- RBC
red blood cell
- POPC
phospholipid 1-palmitoyloleoyl-phosphatidylcholine
- LDH
lactate dehydrogenase
- TB
trypan blue
- SPR
surface plasmon resonance
- P/L max
peptide-to-lipid maximum binding
- FA
formic acid
- BMRB
Biological Magnetic Resonance Bank
- HUVEC
human umbilical vein endothelial cells
- POPS
1-palmitoyloleoyl-phosphatidylserine.