Journal of Biological Chemistry
Volume 294, Issue 29, 19 July 2019, Pages 11286-11296
Protein Structure and FoldingEngineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcomaEnhanced protein disaggregases to counter sarcoma
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open access
heat shock protein (HSP)
protein aggregation
translocation
cancer
chaperone
chromosomal translocation
EWS-FLI
FUS-CHOP
Hsp104
sarcoma
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This work was supported by Washington University startup funds, NIGMS, National Institutes of Health Grants R35GM128772 (to M. E. J.) and R01GM099836 (to J. S.), and an Abramson Cancer Center Sarcoma Pilot Grant (to J. S.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
© 2019 Ryan et al.