Journal of Biological Chemistry
Volume 294, Issue 48, 29 November 2019, Pages 18168-18180
MicrobiologyDouble-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKRADAR1 role in ZIKV replication
Under a Creative Commons license
open access
viral replication
interferon
flavivirus
RNA editing
host-pathogen interaction
post-transcriptional regulation
adenosine deaminase
host factor
positive stranded RNA virus
protein kinase regulated by dsRNA
Zika virus
arbovirus
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This work was supported by National Natural Science Foundation of China Grant 31970887, Guangdong Science and Technology Program Grants 2017A050501012 and 2018A050506029, and Natural Science Foundation of Guangdong Province Grant 2017A030313504. The authors declare that they have no conflicts of interest with the contents of this article.
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The abbreviations used are:
- ZIKV
Zika virus
- E
ZIKV envelope protein
- ADAR
adenosine deaminase acting on dsRNA
- dsRBD
dsRNA-binding domain
- IFN
interferon
- VSV
vesicular stomatitis virus
- PKR
dsRNA-regulated protein kinase
- MOI
multiplicity of infection
- qRT-PCR
quantitative reverse transcription PCR
- p.i.
postinfection
- siNC
negative control siRNA
- GAPDH
glyceraldehyde-3-phosphate dehydrogenase
- sgRNA
single guide RNA
- aa
amino acid(s)
- PMSF
phenylmethanesulfonyl fluoride
- DAPI
4′,6-diamidino-2-phenylindole.
© 2019 Zhou et al.