Journal of Biological Chemistry
Volume 294, Issue 20, May 2019, Pages 8259-8272
Protein Structure and FoldingDynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions
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heme oxygenase
enzyme catalysis
enzyme mechanism
protein dynamics
membrane protein
hydrogen exchange mass spectrometry
enzyme kinetics
conformational change
heme homeostasis
membrane anchor
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This work was supported by National Institutes of Health Grants R01-GM123513 (to S. W. R.) and P30GM103335 and GM061068 (to D. F. B.) and a research collaboration with Waters Corp. (to J. R. E.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This article contains Figs. S1–S6 and Excel File S1.
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Both authors contributed equally to this work.
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Present address: Protein Mass Spectrometry, Analytical R&D, Process R&D, Merck and Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033.
© 2019 Kochert et al.