Journal of Biological Chemistry
ImmunologyA small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities
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This work was supported by National Natural Science Foundation of China Grants 81402830, 31870868, 81603080, 31670930, 31700656, and 81802023; China Postdoctoral Science Foundation Grant 2015M571815; Ministry of Science and Technology of China Grant 2018ZX10731301-001-006; Natural Science Foundation of Jiangsu Province Grant BK20140362 and Fujian Province Grant 2017J05050; Priority Academic Program Development of Jiangsu Higher Education Institutions; Program for Changjiang Scholars and Innovative Research Team in University Grant PCSIRTIRT1075; and Science and Technology Development of Suzhou Grants SNG2017050 and sys2018017. The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Tables S1–S4 and Figs. S1–S8.
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These authors contributed equally to this work.
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The abbreviations used are:
- TB
tuberculosis
- FIC
fractional inhibitory concentration
- FICI
fractional inhibitory concentration index
- Mt. b
Mycobacterium tuberculosis
- MIC
minimum inhibitory concentration
- RU
resonance units
- sAK15
scrambled AK15
- i.v.
intravenous
- TDM
trehalose 6,6′-dimycolate
- BMDM
bone marrow-derived macrophage
- IFN
interferon
- TNF
tumor necrosis factor
- IL
interleukin
- FBS
fetal bovine serum
- TFE
trifluoroethanol.