Journal of Biological Chemistry
Cell BiologyWNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial–mesenchymal transition
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This work was supported by National Science Foundation Grant CBET-1644932 (to D. J. K.) and NCI, National Institutes of Health, Grant R01CA193473 (to D. J. K.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This article contains Tables S1–S3 and Figs. S1–S9.
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The abbreviations used are:
- EMT
epithelial–mesenchymal transition
- EMT-TF
EMT-inducing transcription factor
- qPCR and qRT-PCR
quantitative PCR and quantitative RT-PCR, respectively
- TGF
transforming growth factor
- CCN
cellular communication network
- MAPK
mitogen-activated protein kinase
- ERK
extracellular signal-regulated kinase
- MEK
mitogen-activated protein kinase/extracellular signal-regulated kinase kinase
- PI3K
phosphatidylinositol 3-kinase
- JNK
c-Jun N-terminal kinase
- IHC
immunohistochemistry
- FPKM
fragments per kilobase of transcript per million mapped reads
- 2D and 3D
two- and three-dimensional, respectively
- YUMM
Yale University Mouse Melanoma
- MET
mesenchymal–epithelial transition
- DMEM
Dulbecco's modified Eagle's medium
- FBS
fetal bovine serum
- SFM
serum-free medium.