Journal of Biological Chemistry
Volume 294, Issue 7, 15 February 2019, Pages 2529-2542
EnzymologyStructure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal
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crystal structure
enzyme structure
enzyme catalysis
flavoprotein
protein engineering
tryptophan
biocatalysis
enzyme design
enzyme engineering
FAD-dependent halogenase
enzyme structure-
protein design
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The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Tables S1 and S2 and Figs. S1–S17.
The atomic coordinates and structure factors (codes 6H43, 6H44, and 6IB5) have been deposited in the Protein Data Bank (http://wwpdb.org/).
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Both authors contributed equally to this work.
© 2019 Moritzer et al.