Journal of Biological Chemistry
Mechanisms of Signal TransductionThe Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2*
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The abbreviations used are: TLR, Toll-like receptor; PGN, peptidoglycan; LTA, lipoteichoic acid(s); Pam3CSK4, N-palmitoyl-S-[2,3-bis-(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine; ABC, ATP binding cluster; CHO, Chinese hamster ovary; MS, mass spectrometry; MALDI, matrix-assisted laser desorption/ionization; TOF, time-of-flight.
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This work was supported by National Research Laboratory Grants M10400000028-04J0000-02 and MOST/KOSEF Bioscience Grant 20080576001. This work was also partially supported by the BK21 program. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement”in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Table S1 and Figs. S1 and S2.
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Recipient of the Uehara Memorial Foundation Grant.