Journal of Biological Chemistry
Enzyme Catalysis and RegulationCrystal Structure of Human Liver Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis*♦
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This paper is dedicated to Dr. Paul Talalay, The John Jacob-Abel Distinguished Service Professor, Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, in honor of his 85th birthday. Paul has been a pioneer in steroid hormone enzymology throughout his career.
The atomic coordinates and structure factors (code 3BUR, 3CMF, 3COT, 3BUV, and 3BV7) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
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This work was supported, in whole or in part, by National Institutes of Health Research Grant R01-GM56838 (to D. W. C.) and Grants R01-DK47015 and P30-ES013508 (to T. M. P.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Tables S1 and S2.
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This article was selected as a Paper of the Week.