Journal of Biological Chemistry
Volume 291, Issue 8, 19 February 2016, Pages 3682-3692
Molecular BiophysicsGain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling*♦
Under a Creative Commons license
open access
electrophysiology
ion channel
molecular docking
molecular dynamics
protein-protein interaction
allosteric activation
channelopathies
tetramer model
Cited by (0)
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This work was supported by National Institutes of Health Program Project Grant P01 HL 110873-04. The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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This article was selected as a Paper of the Week.
This article contains supplemental movies.
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M. Shobair, P. Kota, and N. V. Dokholyan, unpublished data.
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A Howard Hughes Medical Institute International Student Research Fellow.
© 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.