Journal of Biological Chemistry
Volume 291, Issue 5, 29 January 2016, Pages 2196-2222
Gene RegulationHigh Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor*
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DNA-protein interaction
heme
ligand-binding protein
metal ion-protein interaction
nuclear receptor
protein-protein interaction
proteolysis
transcription corepressor
transcription repressor
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- *
This work was supported by National Institutes of Health Grants 5R01-HL-102662 (to S. W. R.) and 1F32HL114150 (to E. L. C.) and by Grant T32ES007062 from the NIEHS (to E. L. C.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
© 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.