Journal of Biological Chemistry
Signal TransductionEssential Role of Protein-tyrosine Phosphatase 1B in the Modulation of Insulin Signaling by Acetaminophen in Hepatocytes*
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This work was supported by Grants SAF2012-33283, BFU2011-25420, and AGL2010-17579 from the Ministerio de Economía y Competitividad, Comunidad de Madrid Grant S2010/BMD-2423, European Foundation for the Study of Diabetes and Amylin Paul Langerhans Grant, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, and Grant PI09/0185 from Instituto de Salud Carlos III.
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These authors contributed equally to this work.
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Supported by a Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (Instituto de Salud Carlos III) postdoctoral contract.
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The abbreviations used are:
- APAP
acetaminophen
- PTP1B
protein-tyrosine phosphatase 1B
- IR
insulin receptor
- IRS
insulin receptor substrate
- NAPQI
N-acetyl-p-aminobenzoquinone imine
- LDH
lactate dehydrogenase
- AUC
area under the curve
- EE
energy expenditure.