Signal Transduction
The TGFβ Receptor-interacting Protein km23-1/DYNLRB1 Plays an Adaptor Role in TGFβ1 Autoinduction via Its Association with Ras*

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Background: The TGFβ receptor-interacting protein km23-1 plays an important role in TGFβ signal transduction in TGFβ-sensitive epithelial cells.

Results: The role of km23-1 in TGFβ activation of Ras/JNK/ERK, as well as TGFβ1 autoinduction, was determined.

Conclusion: km23-1 is required for TGFβ1 autoinduction through a Smad2-independent Ras/ERK/JNK pathway.

Significance: km23-1 functions as a critical adaptor coupling TGFβ receptors to Ras activation after TGFβ treatment.

MAP kinases (MAPKs)
Ras
Signal transduction
Signaling
Transforming growth factor beta (TGFbeta)
MAPK
TGFbeta
dynein
km23-1

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*

This work was supported, in whole or in part, by National Institutes of Health Grants CA090765, CA092889, CA100239, and CA092889-08S1 (to K. M. M.).

© 2012 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.