Journal of Biological Chemistry
Volume 287, Issue 6, February 2012, Pages 3659-3673
Signal TransductionSecond Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Differentially Regulates Orthosteric but Not Allosteric Agonist Binding and Function*
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Cell Signaling
G Protein-coupled Receptors (GPCR)
Peptide Hormones
Receptor Structure-Function
Signal Transduction
Allosteric Agonist
Exendin
Glucagon-like Peptide-1 Receptor
Ligand-directed Signaling Bias
Oxyntomodulin
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- *
This work was supported in part by National Health and Medical Research Council of Australia Project Grant 1002180 and Program Grant 519461 and by a National Health and Medical Research Council Principal Research Fellowship (to P. M. S.) and a Senior Research Fellowship (to A. C.).
This article contains supplemental Figs. S1–S3.
- 1
Senior Research Fellow of the National Health and Medical Research Council.
© 2012 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.