Journal of Biological Chemistry
Signal TransductionAnnexin A5 is essential for PKCθ translocation during T-cell activation
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Author contributions—Z. Hu, L. L., X. Z., J. Z., and Z. Hua conceptualization; Z. Hu, L. L., M. L., P. X., and X. Z. resources; Z. Hu, L. L., B. Z., Y. H., X. W., and X. Z. data curation; Z. Hu, L. L., B. Z., and X. Z. formal analysis; Z. Hu, L. L., and X. Z. supervision; Z. Hu, L. L., Y. H., and X. Z. validation; Z. Hu, L. L., B. Z., X. W., X. L., X. Z., and J. Z. investigation; Z. Hu, L. L., and X. Z. visualization; Z. Hu, L. L., M. L., X. Z., and J. Z. methodology; Z. Hu and X. Z. project administration; X. Z. software; X. Z. writing-original draft; X. Z. and J. Z. writing-review and editing; Z. Hua funding acquisition.
Funding and additional information—This study was supported in part by Chinese National Natural Sciences Foundation Grants 81630092 and 81773099 (to Z. H.) and by National Key R&D Research Program, Ministry of Science and Technology, Grant 2017YFA0506002 (to Z. H.).
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- TCR
T-cell receptor
- PKC
protein kinase C
- PS
phosphatidylserine
- TPA
12-O-tetradecanoylphorbol-13-acetate
- ConA
concanavalin A
- IL
interleukin
- ERK
extracellular signal–regulated kinase
- MAPK
mitogen-activated protein kinase
- CBM
CARMA1-Bcl10-MALT1
- KO
knockout.
- ‡
These authors contributed equally to this work.