Journal of Biological Chemistry
Volume 294, Issue 50, 13 December 2019, Pages 19292-19305
RNAContribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation
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open access
hearing
mitochondrial DNA (mtDNA)
transfer RNA (tRNA)
pathogenesis
mitochondrial respiratory chain complex
mitochondrial disease
RNA metabolism
reactive oxygen species (ROS)
mitochondrial metabolism
translation
maternal inheritance
mitochondrial translation
mutation
synergy
hearing loss
mitochondrial tRNA
tyrosyl-tRNA synthetase 2 (YARS2)
pathophysiology
oxidative stress
tRNASer(UCN)
maternally transmitted deafness
genetic disorder
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This work was supported by Ministry of Science and Technology of Zhejiang Province Grant 2018C03026; National Key Technologies R&D Program Grant 2014CB541704 from the Ministry of Science and Technology of China (to M.-X. G.); and National Natural Science Foundation of China Grants 81330024, 31671305, and 81600817 (to M.-X. G., Y. C., and J. Z., respectively). The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Tables S1–S3 and Figs. S1 and S2.
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Both authors contributed equally to this work.
© 2019 Fan et al.