Journal of Biological Chemistry
MetabolismInhibition of Mitochondrial Pyruvate Transport by Zaprinast Causes Massive Accumulation of Aspartate at the Expense of Glutamate in the Retina*
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This work was supported, in whole or in part, by National Institutes of Health Grants EY06641 and EY017863 (to J. B. H.). This work was also supported by grants from the Deutsche Forschungsgemeinschaft (Pa1751/4-1), EU (DRUGSFORD: HEALTH-F2-2012-304963), and the Kerstan Foundation (to F. P.-D.) and the Ministerio de Economíay Competitividad (BFU2011-30456-C02-01/BMC) and Coumunidad Autónoma de Madrid (S2010/BMD-2402) (to J. S.). This work was also funded by the CIBERER, an initiative from the Instituto de Salud Carlos III, and an institutional grant from the Fundación Ramón Areces to the Centro de Biología Molecular Severo Ochoa.
This article contains supplemental Methods and Figs. 1–9.
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Recipient of a Junta De Ampliación de Estudios postdoctoral contract from Consejo Superior de Investigaciones Científicas.