Journal of Biological Chemistry
Volume 285, Issue 24, 11 June 2010, Pages 18650-18661
Protein Structure and FoldingAllosteric Drug Discrimination Is Coupled to Mechanochemical Changes in the Kinesin-5 Motor Core*
Under a Creative Commons license
open access
Allosteric Regulation
ATPases
Drug Action
Drug Resistance
Fourier Transform IR (FTIR)
Kinesin
Molecular Motors
Protein Structure
Multivariate Data Analysis
Cited by (0)
The atomic coordinates and structure factors (code 3KEN) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
- *
This work was supported, in whole or in part, by National Institutes of Health Grant GM066328 (to E. J. W.). This work was also supported by grants from the Louisiana Board of Regents (to S. K. and to D. K. W.), the OSER/Carilion Biomedical Institute (to E. J. W. and S. K.), ASPIRES (to S. K., R. A. W., and E. J. W.), and the National Science Foundation (to R. A. W.).
The on-line version of this article (available at http://www.jbc.org) contains supplemental Movie S1 and Figs. S1–S3.
© 2010 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.