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Synfacts 2008(7): 0741-0741  
DOI: 10.1055/s-2008-1077837
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Suzuki-Miyaura Cross-Coupling of Trifluoroboratohomoenolates

Contributor(s): Paul Knochel, Andrei Gavryushin
G. A. Molander*, D. E. Petrillo
University of Pennsylvania, Philadelphia, USA
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

The application of the corresponding alkyltrifluoroborates as nucleophiles in a cross-coupling reaction with aryl and alkenyl halides or triflates allowed a simple preparation of various 2-arylethyl ketones, amides and esters. The method tolerates a broad variety of functional groups, and, due to its simplicity and excellent versatility, can be very useful in combinatorial synthesis and creation of compound libraries.