Triterpenoid Saponins with Neuroprotective Effects from the Roots of Polygala tenuifolia

 

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Abstract

The methanol fraction of an ethanolic extract from the roots of Polygala tenuifolia Willd. showed antagonistic action on neurotoxicity induced by glutamate and serum deficiency in PC12 cells. Bioassay-guided fractionation led to the isolation of six new triterpenoid saponins, onjisaponins V - Z, and Vg (1 - 6), together with ten known saponins (7 - 16). The structures of 1 - 6 were elucidated by spectroscopic and chemical methods. Screening results indicated that compounds 1 - 16 showed neuroprotective effects against serum deficiency and glutamate at the concentration of 10^-5 mol/L.

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Prof. Dr. Dongming Zhang

Institute of Materia Medica

Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education)

1 Xiannongtan Street

Beijing 100050

People’s Republic of China

Phone: +86-10-6316-5227

Fax: +86-10-6301-7757

Email: zhangdm@imm.ac.cn