Increase of Plasmatic β-Endorphin Immunoreactive Material in Children in the Perioperative Period: The Influence of the Site of Surgery

 

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Abstract

Background: The primary aim of the study was to confirm the increase of plasmatic IR β-endorphin material during the perioperative period in children. The second was to search for the factors responsible for this increment. Methods: Seventy-two consecutive children undergoing a surgical procedure were recruited. Pre-anaesthesia and anaesthesia were standardised. Plasmatic IR β-endorphin material was measured at three timepoints: at baseline (t₀), before induction (t₁), and at the end of anaesthesia (t₂). Two general linear models were set up to analyse the influence of demographics and clinics on the IR β-endorphin variation between t₀ and t₁. A third model was established to process the possible surgical factors contributing to the IR β-endorphin variation between t₁ and t₂. Results: ANOVA showed that IR β-endorphin concentrations increased significantly across the three timepoints (p < 0.0001). Wilcoxon test proved that the difference was significant both for t₀ vs. t₁ and for t₁ vs. t₂. None of the factors taken into account in the pre-operative period influenced the increase in IR β-endorphin between t₀ and t₁. Of the factors taken into account in the surgical period, only the type of procedure was significant (p = 0.005). The t-test showed that IR β-endorphin significantly increased during spermatic and epigastric anastomosis (p = 0.000), orchidopexy (p = 0.02), Van der Meulen urethroplasty (p = 0.004), and Duckett urethroplasty (p = 0.003). Conclusion: Plasmatic β-endorphin increases during the perioperative period in children. The site of surgery is responsible for this increment during intervention.

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M.D. Valeria Bachiocco

Vicolo Broglio 6

40125 Bologna

Italy

Email: valebachiocco@libero.it