Highly Effective Regioselective Method for the Synthesis of Substituted Coumarin­- and Quinolone-Annulated Heterocycles Using a Palladium(0)-Catalyzed­ Reaction

 

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Abstract

The preparation of a variety of tetracyclic ring systems by palladium(0)-catalyzed cyclization of 2-bromobenzyloxy-substituted coumarins and quinolones is described. The process has been found to be a viable method for regioselective synthesis of the corresponding products in very good to excellent yield.

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