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Horm Metab Res 1987; 19(3): 110-114
DOI: 10.1055/s-2007-1011754
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© Georg Thieme Verlag, Stuttgart · New York

Androgen Receptors in Skeletal Muscle Cytosol from Sheep Treated with Trenbolone Acetate

P. A. Sinnett-Smith, Christine A. Palmer, P. J. Buttery
  • Department of Applied Biochemistry and Food Science, University of Nottingham School of Agriculture, Sutton Bonington, Nr. Loughborough, Leics, United Kingdom
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Publication History

1983

1986

Publication Date:
14 March 2008 (online)

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Summary

Female sheep were implanted with the anabolic agent trenbolone acetate and the effects of the treatment on the skeletal muscle androgen receptor studied. In two separate trials the binding capacity/mg skeletal muscle protein was reduced. In trial 1 the animals were implanted (80 mg trenbolone acetate) at the start and after 5 weeks of the trial and samples taken one week later while in the second trial samples were taken 15 days after a single implant (80 mg trenbolone acetate). The ability of a variety of steroids and steroid-like compounds to displace [3H] testosterone and [3H] methyltrienolone was also studied. The androgen receptor was also partially purified using heparin-sepharose chromatography The involvement of the androgen receptor in the mode of action of trenbolone is discussed.

Key-Words

Anabolic Steroids - Skeletal Muscle - Sheep Testosterone - Trenbolone Acetate

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