Horm Metab Res 2004; 36(10): 693-695
DOI: 10.1055/s-2004-826018
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

Lipid Peroxidation at Various Estradiol Concentrations in Human Circulation during Ovarian Stimulation with Exogenous Gonadotropins

H.  Kaya1 , M.  Sezik1 , O.  Ozkaya1 , R.  Dittrich2 , E.  Siebzehnrubl2 , L.  Wildt2
  • 1Department of Obstetrics and Gynecology, Suleyman Demirel University, School of Medicine, Isparta, Turkey
  • 2Department of Obstetrics and Gynecology, Alexander Friedrich University, Erlangen, Germany
Further Information

Publication History

Received 12 February 2004

Accepted after revision 22 June 2004

Publication Date:
03 November 2004 (online)

Abstract

The aim of our study was to investigate the correlation between serum malondialdehyde levels and serum estradiol concentrations in healthy human female subjects. Nine hundred and fifty-five blood samples, from infertile women undergoing controlled ovarian hyperstimulation treatment with recombinant follicle-stimulating hormone, were collected for estradiol and malondialdehyde measurements. Five groups were formed according to serum estradiol levels: Group I (< 50 pg/ml), group II (50 - 299 pg/ml), group III (300 - 999 pg/ml), group IV (1000 - 1999 pg/ml) and group V (≥ 2000 pg/ml). One-way analysis of variance was used for comparisons. Mean malondialdehyde concentrations were 1.74 ± 0.24 mmol/ml (group I), 1.53 ± 0.20 mmol/ml (group II), 1.69 ± 0.24 mmol/ml (group III), 1.77 ± 0.21 mmol/ml (group IV) and 1.86 ± 0.20 mmol/ml (group V), respectively. Mean serum malondialdehyde level at physiological estradiol concentrations (50 - 199 pg/ml, group II) was significantly (p < 0.01) lower than the mean malondialdehyde levels in other groups. Mean malondialdehyde concentrations among the remaining groups did not significantly differ. Our findings suggest that in vivo lipid peroxidation might be increased when circulating estradiol concentrations are below (< 50 pg/ml) or above (> 300 pg/ml) the physiological limits. High blood estradiol levels in human female subjects during ovarian stimulation with exogenous gonadotropins could be associated with increased serum malondialdehyde concentrations.

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H. Kaya

Suleyman Demirel Universitesi Tip Fakultesi · Kadın Hastaliklari ve Dogum Klinigi

32100 Isparta · Turkey

Phone: +90-246-211-2100

Fax: +90-246-237-1762

Email: drhakankaya2002@yahoo.com

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