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Planta Med 2003; 69(9): 869-871
DOI: 10.1055/s-2003-43206
Letter
© Georg Thieme Verlag Stuttgart · New York

Galanthindole: A New Indole Alkaloid from Galanthus plicatus ssp. byzantinus

Nehir Unver1 , G. Irem Kaya1 , Christa Werner2 , Robert Verpoorte3 , Belkıs Gözler1
  • 1Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey
  • 2Organisch-chemiches Institut, Universität Zürich, Zürich, Switzerland
  • 3LACDR, Division of Pharmacognosy, Gorlaeus Laboratories, Leiden, The Netherlands
This research was supported by TÜBITAK (Turkish Scientific and Technical Research Organization) and EBILTEM (The Ege Science and Technology Centre) (Grant No’s: SBAG-2194 and 2001/BIL/019, respectively)
Further Information

Publication History

Received: March 5, 2003

Accepted: May 31, 2003

Publication Date:
04 November 2003 (online)

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Abstract

A new indole alkaloid, galanthindole, was isolated from Galanthus plicatus ssp. byzantinus (Amaryllidaceae), a plant native to northwestern Turkey. Incorporating a non-fused indole ring, galanthindole may represent the prototype of a new subgroup of the Amaryllidaceae alkaloids. Two other bases, (+)-11-hydroxyvittatine and hordenine, are also reported from the same plant.

References

  • 1 Akıneri G, Güneş H S. Galanthus plicatus ssp. byzantinus as a new source for some Amaryllidaceae alkaloids.  J Fac Pharm Gazi. 1998;  15 99-106
    PubMedGoogle Scholar
  • 2 Unver N, Noyan S, Gözler B, Gözler T, Werner C, Hesse M. Four new Amaryllidaceae alkaloids from Galanthus gracilis and Galanthus plicatus subsp. byzantinus .  Heterocycles. 2001;  55 641-52
    PubMedGoogle Scholar
  • 3 Richards S A. Laboratory Guide to Proton NMR Spectroscopy. London; Blackwell Scientific Publications 1988: p. 59
    Google Scholar
  • 4 Hoshino O. The Amaryllidaceae Alkaloids. In: Cordell GA, editor The Alkaloids Chemistry and Pharmacology. Vol. 51 New York; Academic Press Inc 1998: pp. 323-424
    Google Scholar
  • 5 Unver N, Gözler T, Walch N, Gözler B, Hesse M. Two novel dinitrogenous alkaloids from Galanthus plicatus subsp. byzantinus (Amaryllidaceae).  Phytochemistry. 1999;  50 1255-61
    CrossrefPubMedGoogle Scholar
  • 6 Noyan S, Rentsch G H, Önür M A, Gözler T, Gözler B, Hesse M. The gracilines: a novel subgroup of the Amaryllidaceae alkaloids.  Heterocycles. 1998;  48 1777-91
    PubMedGoogle Scholar
  • 7 Wildman W C. Alkaloids of the Amaryllidaceae. In: Manske RHF, Holmes HL, editors The Alkaloids. Chemistry and Physiology. Vol. 6 New York; Academic Press Inc 1960: pp. 289-413
    Google Scholar
  • 8 Uyeo S, Yajima H. Lycoris alkaloids. Part XXXI. A structural inter-relationship of lycorine and lycorenine. J Chem Soc 1955: 3392-95 Unver N Isolation and structure elucidation studies on the alkaloids of Galanthus plicatus Bieb. subsp. byzantinus (Baker) D. A. Webb (Amaryllidaceae) wildly growing around Lake Abant, Bolu Ph. D. Thesis 1999 Ege University, İzmir, Turkey Ghosal S Srivastava R S β-phenethylamine, tetrahydroisoquinoline and indole alkaloids of Desmodium tiliaefolium Phytochemistry 1973 12 193 7 Kruger T L Cooks R G McLaughlin J L Raineri R L Identification of alkaloids in crude extracts by mass-analyzed ion kinetic energy spectrometry J Org Chem 1977 42 4161 2 Srinivasan P R Lichter R L 13C-NMR spectral studies of arecoline, hordenine, strychnine and brucine Org Magn Res 1976 8 198 201 Tato M PV Castedo L Riguera R New alkaloids from Pancratium maritimum L Heterocycles 1988 27 2833 8 Mügge C Schablinski B Obst K Döpke W Alkaloids from Hippeastrum hybrids Pharmazie 1994 49 444 7 Pham H Gründemann E Döpke W Alkaloids from Hippeastrum equestre Herb. (Amaryllidaceae) Pharmazie 1997 52 160 3
    PubMedGoogle Scholar

Belkis Gözler

Ege University

Faculty of Pharmacy

Bornova

35100 Izmir

Turkey

Fax: +90-232-3885258

Email: gozlerb@eczacilik.ege.edu.tr

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