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Synlett 2001; 2001(Special Issue): 0980-0982
DOI: 10.1055/s-2001-14639
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The First Enantioselective and Diastereoselective Catalytic Nitro-Mannich Reaction: A New Entry to Chiral Vicinal Diamines

Ken-ichi Yamada* , Guido Moll, Masakatsu Shibasaki
  • *Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Fax + 81 (3) 56 84 52 06; E-mail: mshibasa@mol.f.u-tokyo.ac.jp
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Publication Date:
31 December 2001 (online)

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The first example of an enantioselective and diastereoselective catalytic nitro-Mannich reaction using a second-generation heterobimetallic complex has been developed. The corresponding nitro-Mannich products were obtained in up to 83% ee with a dr up to 7 : 1.

1,2-diamines - asymmetric catalysis - imines - nitro compounds - nucleophilic additions

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