Thromb Haemost 1999; 82(S 01): 32-37
DOI: 10.1055/s-0037-1615550
Commentaries
Schattauer GmbH

Oxidative Stress and Atherosclerosis: Its Relationship to Growth Factors, Thrombus Formation and Therapeutic Approaches

Johannes Ruef
,
Karlheinz Peter
,
Thomas K. Nordt
,
Marschall S. Runge
1   Division of Cardiology, University of Texas Medical Branch, Galveston, Texas, USA
,
Wolfgang Kübler
,
Christoph Bode
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2017 (online)

Summary

The initiating event of atherogenesis is thought to be an injury to the vessel wall resulting in endothelial dysfunction. This is followed by key features of atherosclerotic plaque formation such as inflammatory responses, cell proliferation and remodeling of the vasculature, finally leading to vascular lesion formation, plaque rupture, thrombosis and tissue infarction. A causative relationship exists between these events and oxidative stress in the vessel wall. Besides leukocytes, vascular cells are a potent source of oxygen-derived free radicals. Oxidants exert mitogenic effects that are partially mediated through generation of growth factors. Mitogens, on the other hand, are potent stimulators of oxidant generation, indicating a putative self-perpetuating mechanism of atherogenesis. Oxidants influence the balance of the coagulation system towards platelet aggregation and thrombus formation. Therapeutic approaches by means of antioxidants are promising in both experimental and clinical designs. However, additional clinical trials are necessary to assess the role of antioxidants in cardiovascular disease.

 
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